目的对比口服降糖药及胰岛素治疗对胰岛功能的影响。方法2型糖尿病患者60人随机分两组,一组常规口服降糖药,一组胰岛素强化治疗。病初行糖耐量或馒头餐进行胰岛功能测定,治疗后1年复查胰岛功能。结果30例口服降糖药患者1年后胰岛素水平均略有下降;30例胰岛素强化治疗患者胰岛素水平未降或有所改善(P<0.05)。结论早期胰岛素强化治疗对胰岛内生功能有保护作用。 Objective To compare the effects of oral hypoglycemic agents and insulin therapy on islet function. Methods Sixty patients with type 2 diabetes were randomly divided into two groups, one group of conventional oral hypoglycemic agents and one group of insulin intensive treatment. In the initial stage of the disease, glucose tolerance or bread meal was used to measure islet function, and islet function was reviewed one year after treatment. Results In 30 patients with oral hypoglycaemic agents, the level of insulin decreased slightly after one year; insulin levels in 30 patients with insulin-intensive therapy did not decrease or improved (P<0.05). Conclusion Early intensive insulin therapy has protective effects on the endogenous function of islets.