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目的探讨慢性阻塞性肺疾病(COPD)急性加重期凝血功能的变化。方法对78例COPD急性加重期患者、55例COPD稳定期患者和20例健康体检者检测4项凝血(PT、APTT、TT、Fbg)和D-二聚体,用SPSS14.0软件进行单因素方差分析。结果急性加重期患者Fbg和D-二聚体含量显著高于稳定期患者和正常对照组,稳定期含量也明显高于正常对照组(P<0.05),PT、APTT、TT含量在三组间差异无统计学意义(P>0.05)。结论对COPD患者进行监测Fbg和D-二聚体水平,有助于采取有效的防治措施,可控制病情的发展,改善疾病的预后。
Objective To investigate the changes of coagulation function in acute exacerbation of chronic obstructive pulmonary disease (COPD). Methods Four coagulation factors (PT, APTT, TT, Fbg) and D-dimer were detected in 78 patients with exacerbation of COPD, 55 patients with stable COPD and 20 healthy controls. SPSS14.0 software was used to analyze single factor variance analysis. Results The levels of Fbg and D-dimer in patients with acute exacerbation were significantly higher than those in stable patients and normal controls (P <0.05). The levels of PT, APTT and TT in the three groups The difference was not statistically significant (P> 0.05). Conclusions Monitoring the levels of Fbg and D-dimer in patients with COPD can help to take effective prevention and control measures to control the progression of the disease and improve the prognosis of the disease.