论文部分内容阅读
目的探讨珠海市人群肺癌的相关危险因素。方法采用1∶1配对的病例对照研究方法,选取肺癌死亡个案及对照各131例,调查其一般情况、生活居住环境、工作环境、饮食习惯、生活方式、健康和精神状况等与肺癌有关的7个方面,对疾病史、肿瘤家族史、吸烟、被动吸烟、饮酒、煤炉使用年限、房屋通风、职业史、居住地点和工作时间等45个因素采用条件logistic回归方法进行单因素和多因素分析,筛选主要危险因素。结果多因素logistic回归分析显示,吸烟(OR=2.309)、肿瘤家族史(OR=3.348)、厨房油烟大(OR=3.726)、房子通风差(OR=7.989)与肺癌死亡有关(P<0.05)。剂量-反应分析显示吸烟与肺癌发病呈剂量反应关系(P<0.05),吸烟少于10支、10～19支、20～40支组的OR值分别为3.250、2.158、3.431。结论吸烟、肿瘤家族史、厨房油烟大、房子通风差可能是珠海市部分人群肺癌主要危险因素。加强控烟和改善居住环境是预防肺癌的重要措施。
Objective To explore the risk factors of lung cancer in the population of Zhuhai City. Methods 1:1 paired case-control study was used. One hundred and thirty-one cases of lung cancer deaths and controls were selected to investigate their general conditions, living environment, working environment, eating habits, lifestyle, health and mental status and other related to lung cancer. On the other hand, 45 factors, including disease history, family history of cancer, smoking, passive smoking, alcohol consumption, age of coal stoves, ventilation, occupational history, place of residence, and working time, were analyzed by univariate and multivariate analysis using conditional logistic regression. , screening for major risk factors. Results Multivariate logistic regression analysis showed that smoking (OR=2.309), cancer family history (OR=3.348), large kitchen fume (OR=3.726), poor house ventilation (OR=7.989) were associated with lung cancer death (P<0.05). . Dose-response analysis showed that there was a dose-response relationship between smoking and lung cancer (P<0.05). The OR values of smoking less than 10, 10 to 19, and 20 to 40 groups were 3.250, 2.158, and 3.431, respectively. Conclusions Smoking, family history of cancer, large cooking fumes and poor house ventilation may be the main risk factors for lung cancer in some population in Zhuhai. Strengthening tobacco control and improving the living environment are important measures to prevent lung cancer.