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目的通过对江苏淮安地区60岁以上无肾损伤表现老年人群进行调查,了解老年慢性肾疾病(CKD)的患病情况,以提高对CKD的认识,并以中医药进行临床干预,延缓其向尿毒症发展。方法选用Cockcroft-Gault公式计算肾小球滤过率(GFR),按照2002年美国国家肾脏基金会的肾脏病转归质量会议(K/DOQI)提出的标准诊断CKD并分期。将88例CKD 3、4期患者随机分为两组,中药观察组46例除采用常规治疗外加用中药治疗,对照组42例仅进行常规治疗。结果在300例患者中发现CKD 3、4期者88例,检出率高达29.7%。经中医药治疗3个月后,观察组的GFR为(68.8±9.0)ml.min-1.1.73 m-2,对照组的为(40.5±9.2)ml.min-1.1.73 m-2,差异有统计学意义(t=3.86,P<0.05),且使用中药治疗后无不良反应发生。结论 60岁以上无肾损伤表现的老年人CKD检出率较高;中药治疗有效,而且无明显不良反应。
OBJECTIVE: To investigate the prevalence of chronic kidney disease (CKD) in elderly patients over 60 years of age in Huai’an, Jiangsu province, to understand the prevalence of CKD, and to improve the understanding of CKD by clinical intervention with traditional Chinese medicine to delay its progression to uremia Disease development. Methods GFR was calculated by Cockcroft-Gault formula, and CKD was diagnosed and staged according to the standard presented by the National Kidney Disease Quality Assurance Conference (K / DOQI) in 2002 by the National Kidney Foundation. Eighty-eight CKD patients with stage 3 and stage 4 were randomly divided into two groups. Forty-six patients in the traditional Chinese medicine observation group were treated with conventional therapy plus traditional Chinese medicine, and 42 in the control group were treated only routinely. Results Among 300 patients, 88 cases were found CKD stage 3,4 and the detection rate was as high as 29.7%. After three months of treatment with Chinese medicine, the GFR in the observation group was (68.8 ± 9.0) ml.min-1.1.73 m-2, while that in the control group was (40.5 ± 9.2) ml.min-1.1.73 m-2 The difference was statistically significant (t = 3.86, P <0.05), and no adverse reactions occurred after treatment with traditional Chinese medicine. Conclusions The detection rate of CKD in the elderly with no renal injury over 60 years old is higher. Chinese medicine is effective and has no obvious adverse reactions.