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在活体上和体外已经观察到,肿瘤坏死因子(TNF)具有强大的选择性杀伤肿瘤细胞的作用。Sato 等人报告,小鼠用卡介苗(BCG)致敏后,纯化蛋白衍生物(PPD)成功地诱发 TNF 的生成,本文报告一例肾癌转移病人,用 PPD 和 OK-432(链球菌菌体制剂)诱发内源性 TNF 生成,以减少肿瘤的转移性损害.患者男性,55岁,患肾细胞癌,1983年10月行肾切除术,术后5个月出现肺部转移,化疗3个月,转移灶消失,但3个月后又复发,再次化疗无效。病人结核菌素反应强阳性,与小鼠 BCG 致敏状
It has been observed in vivo and in vitro that tumor necrosis factor (TNF) has a strong selective killing effect on tumor cells. Sato et al. reported that a purified protein derivative (PPD) successfully induced TNF production after sensitization with BCG (BCG) in mice. This article reports a case of kidney cancer metastasis using PPD and OK-432 (Streptococcus preparations). ) Induced endogenous TNF production to reduce the metastatic lesions of the tumor. The patient was male, 55 years old, with renal cell carcinoma. Nephrectomy was performed in October 1983. Pulmonary metastasis occurred 5 months after surgery. Chemotherapy for 3 months The metastases disappeared, but they relapsed after 3 months and chemotherapy was not effective again. Patients with strong tuberculin-positive reaction, and mice with BCG sensitization