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目的 :探讨头孢曲松钠对围术期抗感染的作用。方法 :28例胆石症伴炎症需行腹腔镜胆囊切除术患者 ,于麻醉前1h～1 5h肌肉注射头孢曲松钠1g ,于术前、术中、术后分别取血液、胆汁 ,采用紫外分光光度法测定其浓度。结果 :血药浓度术前为 (37 59±16 13) μg/ml,术中为 (49 68±10 51) μg/ml,术后为 (27 09±12 38) μg/ml;给药后2h血药浓度达高峰值 ( (49 68±28 51) μg/ml) ,此刻胆汁药物浓度为血药浓度的4倍 ( (201 77±20 16) μg/ml)。结论 :给药后8h ,血药浓度为该药MIC的49倍以上 ,对围术期可能发生的感染有积极预防和治疗作用
Objective: To investigate the effect of ceftriaxone on perioperative anti-infection. Methods: 28 cases of cholelithiasis with inflammation were treated with laparoscopic cholecystectomy, 1h ~ 15h before anesthesia intramuscular injection of ceftriaxone 1g, respectively, before surgery, intraoperative and postoperative were taken blood, bile, using ultraviolet spectroscopy Spectrophotometric determination of its concentration. Results: The plasma concentration was (37 59 ± 16 13) μg / ml preoperatively and (49 68 ± 10 51) μg / ml postoperatively and (27 09 ± 12 38) μg / ml postoperatively respectively (49 68 ± 28 51) μg / ml). The bile concentration was 4 times (201 77 ± 20 16) μg / ml at 2h. CONCLUSION: After 8h, the plasma concentration is more than 49 times of that of the drug MIC, which has a positive preventive and therapeutic effect on possible infections during the perioperative period