论文部分内容阅读
目的观察慢性肾功能衰竭患者体内脂质过氧化物及抗氧化酶活性的水平,并观察血液灌流对其的影响及可能机制。方法选择慢性肾功能衰竭患者60例,随机分为两组:血液灌流串联血液透析组(HP+HD组)和单纯血液透析组(HD组),每组各30例,分别于治疗前、后采血;健康人25名作为对照组;分别检测血浆中丙二醛(MDA)、超氧化物歧化酶(SOD)、总抗氧化能力(TAC)、谷胱甘肽过氧化物酶(GSH-Px)的水平。结果①透析及灌流治疗前两组患者血MDA、SOD水平均高于正常对照组,血TAC、GSH-Px水平均低于正常对照组,差异有统计学意义(P<0.05),两组治疗前各因子水平差异无统计学意义(P>0.05);②治疗后两组患者血MDA水平较治疗前明显降低,血SOD、TAC、GSH-Px水平均较治疗前明显升高,差异有统计学意义(P<0.05);③血液灌流串联血液透析组治疗后血MDA降低的水平、GSH-Px升高的水平较单纯血液透析组差异有统计学意义(P<0.05),而血SOD、TAC与透析组差异无统计学意义(P>0.05)。结论慢性肾衰竭患者存在着严重的氧化与抗氧化失衡,血液灌流是其有效的治疗手段。
Objective To observe the levels of lipid peroxides and antioxidant enzymes in patients with chronic renal failure and to observe the effect of hemoperfusion on them and its possible mechanism. Methods Sixty patients with chronic renal failure were randomly divided into two groups: hemodialysis group (HP + HD group) and hemodialysis group (HD group), with 30 cases in each group. Before and after treatment, 25 healthy people served as the control group. Plasma malondialdehyde (MDA), superoxide dismutase (SOD), total antioxidant capacity (TAC) and glutathione peroxidase (GSH-Px )s level. Results ① The blood levels of MDA and SOD in the two groups before dialysis and perfusion were significantly higher than those in the normal control group. The levels of TAC and GSH-Px in blood were lower than those in the normal control group (P <0.05) (P> 0.05); ② After treatment, the levels of blood MDA in the two groups were significantly lower than those before treatment, and the levels of SOD, TAC and GSH-Px in blood were significantly higher than those before treatment, with statistical differences (P <0.05); ③The level of MDA decreased after hemoperfusion in series hemodialysis group, the level of GSH-Px increased significantly compared with hemodialysis group (P <0.05) There was no significant difference between TAC and dialysis group (P> 0.05). Conclusion There is a serious imbalance of oxidation and antioxidation in patients with chronic renal failure. Hemoperfusion is an effective treatment.