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我们曾观察到侧脑室注射微量黄腐酸(Fulvic Acid简称FA)对大鼠应激性胃粘膜损伤具有明显的预防作用。本工作的目的观察皮下注射FA能否有同样的作用。这在临床应用上将有一定的意义。 方法 选用体重130～200克的雄性大鼠进行实验。将禁食24小时的大鼠皮下注射FA,对照组注射同量的生理盐水,10-15分钟后给予水浸-束缚刺激,即将大鼠四肢捆在铁丝网上,置于23～25℃水浴中,水深与剑突齐,4小时后将动物处死,观察胃粘膜损伤情
We have observed that intracerebroventricular injection of trace fulvic acid (FA) has a significant preventive effect on stress-induced gastric mucosal injury in rats. The purpose of this study is to observe whether the subcutaneous injection of FA can have the same effect. This will have a certain significance in clinical application. Methods Male rats weighing 130-200 g were selected for the experiment. Rats that were fasted for 24 hours were injected subcutaneously with FA, and control groups were injected with the same amount of physiological saline. After 10-15 minutes, water-inhibition stimulation was performed, i.e., the rat limbs were tied to a barbed wire and placed in a water bath of 23-25C. , Depth of water and xiphoid process, animals were sacrificed 4 hours later to observe gastric mucosal damage