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目的研究放射结合高剂量（ＨＤＲ）腔内放疗及同期化疗治疗食管癌的疗效。方法于１９９４年４月～１９９６年９月，９０例食管癌随机分为两组：４６例用６０Ｃｏ外照射，ＤＴ５０００～５５００ｃＧｙ，１周后，用ＨＤＲ１９２Ｉｒ腔内治疗１０００～１２００ｃＧｙ，ＰＦ化疗方案于第１、５６或６３天各给予一疗程（综合组）；４４例用６０Ｃｏ外照射，ＤＴ６０００～７０００ｃＧｙ（对照组）。结果一、三年生存率，综合组分别为８０％（３６／４６）、４１％（９／２２），对照组分别为３９％（１７／４４）、１１％（２／１８），生存率对比有显著性差异，综合组血液学毒副反应明显。结论外照射结合ＨＤＲ１９２Ｉｒ腔内放疗及同期化疗是晚期食管癌的有价值的综合治疗。
Objective To investigate the efficacy of radiotherapy combined with high-dose (HDR) intraluminal radiotherapy and concurrent chemotherapy for esophageal cancer. Methods From April 1994 to September 1996, 90 cases of esophageal cancer were randomly divided into two groups: 46 cases with 60Co external irradiation, DT 5000-5500 cGy, 1 week later, with HDR192Ir endovascular treatment 1000 ~ 1200 cGy, PF chemotherapy program On the 1st, 56th or 63rd days, one course of treatment was given (comprehensive group); 44 cases were treated with 60Co external radiation and DT6000-7000cGy (control group). Results One-year and three-year survival rates were 80% (36/46) and 41% (9/22) in the comprehensive group and 39% (17/44), 11% (2/18) in the control group, respectively. There were significant differences in the comparison, and the hematologic toxicity of the comprehensive group was obvious. Conclusion External irradiation combined with HDR192Ir intracavitary radiotherapy and concurrent chemotherapy is a valuable comprehensive treatment for advanced esophageal cancer.