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【目的】探讨早产儿血清胃泌素(gastrin,GAS)水平与喂养量的相关性。【方法】将42例早产儿分为观察组(有喂养不耐受)22例与对照组(无喂养不耐受)20例。两组患儿分别在生后24h内及7日龄后行血清胃泌素水平的测定,观察两组患儿治疗一周后临床状况改善情况。【结果】观察组在入院时的血清胃泌素水平及当日每公斤体重奶量较对照组显著减低,治疗7d后两组血清胃泌素水平差异无统计学意义;观察组在达全量肠内营养时间、恢复至出生体重时间较对照组显著延长(P<0.05或<0.01),而在住院期间血清总胆红素水平高峰值及血清前白蛋白水平方面差异无统计学意义(P>0.05)。两组患儿均未发生一例坏死性小肠结肠炎,吸入性肺炎等严重的喂养并发症。两组患儿血清胃泌素水平与检测当日每公斤体重奶量的相关性分析呈正相关(r=0.589,P<0.01)。【结论】早产儿血清GAS水平与胃肠功能紊乱的发生关系密切,微量喂养可促进早产儿胃肠道发育成熟。
【Objective】 To investigate the correlation between serum gastrin (GAS) level and feeding amount in premature infants. 【Methods】 Forty-two premature infants were divided into observation group (with feeding intolerance) and control group (n = 20). The levels of serum gastrin in the two groups were measured respectively within 24 hours and 7 days after birth, and the improvement of clinical condition was observed after one week of treatment in both groups. 【Results】 The levels of serum gastrin and the amount of milk per kilogram of body weight on admission in the observation group were significantly lower than those in the control group. There was no significant difference in serum gastrin levels between the two groups after 7 days of treatment. (P <0.05 or <0.01), while there was no significant difference in peak value of serum total bilirubin and serum prealbumin during hospitalization (P> 0.05 ). Neither group of children suffered from severe necrotizing enterocolitis, aspiration pneumonia and other serious feeding complications. There was a positive correlation between serum gastrin levels and milk yield per kilogram body weight on the test day (r = 0.589, P <0.01). 【Conclusion】 The serum level of GAS in preterm infants is closely related to the occurrence of gastrointestinal disorders. Trace feeding can promote the development of gastrointestinal tract in premature infants.