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淋巴结转移是肿瘤转移的重要途径,也是判断预后的主要指标。随着淋巴管内皮标记物的发现,关于肿瘤如何诱导淋巴管生成及促进肿瘤的淋巴结转移成为研究的热点。现将肿瘤淋巴管生成及其调节、淋巴管内皮标记物以及淋巴管生成与肿瘤转移诸方面作一综述。
Lymph node metastasis is an important way of tumor metastasis, but also to determine the prognosis of the main indicators. With the discovery of endothelial markers of lymphatic vessels, it has become a hot research topic on how the tumor induces lymphangiogenesis and promotes the metastasis of the tumor. Now the tumor lymphangiogenesis and regulation, lymphatic endothelial markers and lymphangiogenesis and tumor metastasis are reviewed.