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目的探讨阿昔洛韦致急性肾功能衰竭(ARF)的主要原因及防治措施。方法查阅《中国医院知识仓库(CHKD)全文期刊库》2006～2009年阿昔洛韦致泌尿系统损害的有关文献(19例),进行统计、分析。结果阿昔洛韦致急性肾功能衰竭发生的频度虽然不高,但其危害极大,且主要由于不合理用药所致,如超适应证用药、用药量过大、滴注浓度过高、滴速过快、不合理配伍等。结论临床医师、药师应重视阿昔洛韦所致的泌尿系统严重不良反应,严格把握用药指针,确保临床合理用药。
Objective To investigate the main causes and prevention and treatment of acyclovir-induced acute renal failure (ARF). Methods To review the related articles (19 cases) of acyclovir-induced urinary system damage from 2006 to 2009 in Chinese Journal of General Hospital Knowledge Library (CHKD), and analyze the data. Results Acyclovir caused acute renal failure frequency is not high, but its great harm, and mainly due to irrational drug use, such as the use of drugs, excessive dosage, overdose, Dripping speed too fast, unreasonable compatibility and so on. Conclusion Clinicians and pharmacists should attach great importance to the urinary system serious adverse reactions caused by acyclovir, and strictly grasp the medication guidelines to ensure clinical rational use of drugs.