目的观察残黄片对α-萘异硫氰酸酯所致大鼠黄疸模型的退黄作用。方法将48只SD大鼠随机分为6组:正常对照组、α-萘异硫氰酸酯模型对照组、茵栀黄颗粒阳性药物组、残黄片低、中、高(0.175、0.350、0.700mg·kg~(-1))剂量组。各给药组连续给药7d,最后1次给药后1h,按75mg·kg~(-1)体质量灌服α-萘异硫氰酸酯诱发大鼠黄疸模型,正常对照组给等量大豆油,48h后大鼠股静脉取血,测定血清总胆红素、胆固醇和总胆汁酸含量;72h后,腹主动脉取血,检测血清丙二醛含量和超氧化物歧化酶活性,同时肝脏组织切片,观察病理学改变。结果与正常对照组比较,模型组大鼠血清总胆红素含量及丙二醇含量明显升高(P<0.01),超氧化物歧化酶活性明显降低(P<0.01),残黄片能明显对抗这种改变;肝脏组织病理学检查证实,残黄片能减轻中毒大鼠肝细胞损伤程度。结论残黄片退黄作用肯定,初步研究结果提示其作用机制与改善胆汁代谢过程和抗自由基氧化损伤有关。 Objective To observe the antipyretic effect of Yuhuang tablet on rat jaundice induced by α-naphthalene isothiocyanate. Methods 48 Sprague-Dawley rats were randomly divided into 6 groups: normal control group, α-naphthalene isothiocyanate model control group, Yinzhihuang granule-positive drug group, residual yellow tablets low, middle and high (0.175,0.350,0.700 mg · kg -1) dose group. Each administration group was administrated continuously for 7 days and 1 hour after the last administration, the model of jaundice was induced by α-naphthalene isothiocyanate in 75 mg · kg -1 body weight, and the normal control group was given equal amount Soybean oil was taken from the femoral vein of rats for 48 hours to measure the content of total bilirubin, cholesterol and total bile acid. After 72 hours, the blood was taken from the abdominal aorta to measure the content of serum malondialdehyde and the activity of superoxide dismutase Liver tissue sections were observed pathological changes. Results Compared with the normal control group, the content of serum total bilirubin and the content of propanediol in the model group were significantly increased (P <0.01) and the activity of superoxide dismutase (P <0.01) significantly decreased Changes; liver histopathological examination confirmed that residual yellow tablets can reduce the degree of hepatotoxicity in rats poisoning. Conclusion The effect of remnant yellow tablets on yellowing is affirmed. The preliminary results suggest that its mechanism of action is related to the improvement of bile metabolism and anti-free radical oxidative damage.