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为了解非甲非乙型肝炎(NANBH)患儿中丙型肝炎(HC)的发病情况及临床特点,我们用ELISA和叠套式聚合酶链反应(“nested”PCR)技术,检测了57例NANBH患儿(1.7～14岁)血清中抗丙型肝炎病毒抗体(抗HCV)及HCV RNA。结果57例中39例(68.4％)为HCV感染标志阳性。在不同性别、年龄组及不同临床类型(急性或慢性)之间HCV检出率无显著差异。在有、无输血史患儿之间,其检出率比较分别为86.8％和31.5％,差异有非常显著意义(P<0.01)。15例患儿的30名家长中只有1例抗HCV阳性。提示:本地区NANBH患儿中丙型肝炎(HC)占较大比例,输血很可能是本地区HCV感染的主要传播途径。8例HC患儿肝活检组织病理学检查结果表明,HC患儿有发展为慢性肝炎的趋势。
To understand the incidence and clinical characteristics of hepatitis C (HCV) in children with non-A, non-B hepatitis (NANBH), we used ELISA and nested PCR to detect Anti-hepatitis C virus antibodies (anti-HCV) and HCV RNA in serum of 57 NANBH children (aged 1.7-14 years). Results Of the 57 cases, 39 (68.4%) were positive for HCV infection. There was no significant difference in the detection rate of HCV between different sexes, age groups and different clinical types (acute or chronic). The detection rate was 86.8% and 31.5% respectively between children with and without blood transfusion, the difference was significant (P <0.01). Only one out of 30 parents in 15 children was anti-HCV positive. Tip: Hepatitis C (HC) accounted for a large proportion of children with NANBH in this area. Transfusion may be the main route of transmission of HCV infection in this area. Histopathological examination of liver biopsies in 8 children with HC showed that children with HC had a tendency to develop chronic hepatitis.