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作者用免疫组化S－P法观察癌基因c－erbB－2和P21在51例胃、喉及膀胱良恶性病变中的定位、表达。结果显示：c－erbB－2、P21阳性表达主要见于恶性病变即胃癌、喉癌及膀胱癌，而且大部分表现为超表达，在良性病变，癌旁取材，粘膜上皮重度不典型增生的细胞内阳性表达较高，其阳性率P21为77．8％，c－erbB－2为55.6％说明在恶性肿瘤的早期已有癌基因的出现．由此可见癌基因与肿瘤的发生有着密切关系，当癌基因在不典型增生的上皮细胞内出现表达或过度表达时，可做为判断恶性病变的一项客观指标。
The authors used immunohistochemical S-P method to observe the localization and expression of oncogene c-erbB-2 and P21 in 51 cases of benign and malignant lesions of the stomach, larynx and bladder. The results showed that the positive expression of c-erbB-2 and P21 was mainly found in malignant lesions, namely gastric cancer, laryngeal cancer and bladder cancer, and most of them showed overexpression in benign lesions, adjacent tissues, and severe dysplasia of mucosal epithelium. The positive expression was high, the positive rate of P21 was 77.8%, and c-erbB-2 was 55.6%, indicating the presence of oncogenes in the early stages of malignant tumors. This shows that oncogene is closely related to the occurrence of tumors. When oncogenes are expressed or overexpressed in atypical hyperplasia epithelial cells, they can be used as an objective index to judge malignant lesions.