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目的分析自发细菌性腹膜炎(spontaneous bacterlal peritonitis,SBP)应用胸腺肽α_1联合抗菌药物治疗的临床效果。方法选取SBP患者76例,按照完全抽样法1∶1均分为2组(n=38)。对照组予头孢哌酮/舒巴坦抗感染,研究组在对照组基础上予胸腺肽α_1治疗,比较2组治疗后的临床症状改善与T淋巴细胞亚群指标变化情况。结果研究组患者的退热、压痛消失、腹水消失、培养阴性与肝功能改善时间均比对照组短,治疗后的CD3~+、CD 4~+T细胞比例、CD 4~+/CD 8~+比治疗前对照组高,差异均有统计学意义(P<0.05)。结论胸腺肽α_1联合抗菌药物治疗SBP,能够缩短临床症状消失时间,改善机体免疫状态。
Objective To analyze the clinical effect of thymosin α_1 combined with antimicrobial agents in spontaneous bacterial peritonitis (SBP). Methods 76 patients with SBP were selected and divided into 2 groups according to the method of complete sampling 1: 1 (n = 38). The control group was treated with cefoperazone / sulbactam. The study group was treated with thymosin α_1 on the basis of the control group. The clinical symptoms and the change of T lymphocyte subsets in the two groups were compared. Results The fever, tenderness and disappearance of ascites in the study group were shorter than those in the control group. The percentage of CD3 ~ +, CD4 ~ + T cells, CD 4 ~ + / CD8 ~ + Than the control group before treatment, the differences were statistically significant (P <0.05). Conclusion Thymosin α_1 combined with antimicrobial agents for the treatment of SBP can shorten the disappearance of clinical symptoms and improve the immune status.