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用紫杉醇（Ｔａｘｏｌ）治疗３０例难治性卵巢上皮癌和输卵管癌，每例均为对含顺铂或卡铂在内的多种抗癌药耐药患者（半数病例对５种以上抗癌药耐药），均经体检或影像学确诊。完全缓解４例，占１３％，平均缓解期为５个月。部分缓解８例，占２７％，平均缓解期为３．９个月。毒副反应：白细胞总数Ⅲ度下降占３０％，中性粒细胞数下降Ⅲ＋Ⅳ度者占３０％；超敏反应，见６例用药时出现面部潮红；脱发严重，占１００％；胃肠反应、神经毒性及心、肝、肾毒性等均不严重。紫杉醇对难治性卵巢癌和输卵管癌的疗效肯定，毒副反应不重，是日前治疗耐药性卵巢癌的良好药物。
Treatment of refractory ovarian epithelial and fallopian tube cancers with paclitaxel (Taxol). Each case was resistant to multiple anticancer drugs including cisplatin or carboplatin (half of the cases had more than five anticancer drugs). Drug resistance) were confirmed by physical examination or imaging. Complete remission in 4 cases, accounting for 13%, the average remission period was 5 months. Partial remission occurred in 8 cases, accounting for 27%, with an average remission period of 3.9 months. Toxic side effects: The total number of white blood cells decreased by 30%, and the number of neutrophil decreased by III+IV, accounting for 30%; hypersensitivity reaction, see facial flushing in 6 cases of drug use; severe hair loss, accounting for 100%; gastrointestinal reactions, Neurotoxicity and heart, liver and kidney toxicity were not serious. Paclitaxel is effective for treating refractory ovarian and fallopian tube cancers, and its toxicity is not important. It is a good drug for the treatment of drug resistant ovarian cancer.