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目的 :探讨简化TRH兴奋试验及敏感TSH基础测定取代TRH兴奋试验作为Graves病停药指标的可行性。方法 :比较敏感TSH基础值 (bTSH)与TRH兴奋后各时间点TSH值以及反应值 (△TSH)之间的相关性。结果 :bTSH与 30min ,6 0min和 90minTSH值均明显相关 (均P <0 .0 0 1) ,与△TSH亦显著相关 (P <0 .0 0 1)。以bTSH反映△TSH敏感性为 77.2 % ,特异性为 85 .0 %。结论 :TRH兴奋试验时 90min这一次抽血已无必要 ;但 6 0min的点尚不可以随便省略 ;bTSH尚不可以取代TRH试验作为Graves病的停药指标。
Objective: To explore the feasibility of simplifying the TRH excitement test and the sensitive TSH basal assay to replace the TRH excitement test as an index of stopping Graves disease. Methods: The correlation between the TSH basal value (TSH) and the TSH value (TSH) at each time point after TSH stimulation was compared. Results: bTSH was significantly correlated with TSH values at 30 min, 60 min and 90 min (all P <0.01), and significantly correlated with TSH (P <0.01). The bTSH response △ TSH sensitivity was 77.2%, specificity was 85.0%. CONCLUSION: It is unnecessary to draw the blood at 90 min during the TRH stimulation test; however, the point of 60 min can not be omitted at will; the TRH test can not replace the TRH test as the stop indicator of Graves disease.