最近发现的人畜共患H3N2型变异甲型流感病毒(H3N2v)已导致有记录的343例与猪接触相关的人类感染。需要研制针对病毒的有效疫苗,这些病毒可能获得了在人群中的遗传稳定性。然而,从人体中分离的病毒在鸡胚中不能良好复制,这构成了基于鸡胚的疫苗生产的障碍。为了解决这个问题,我们想得到表面蛋白的鸡胚适应性突变以在保留免 The recently discovered zoonotic H3N2 variant A (H3N2v) has resulted in a documented 343 human-related human infections associated with swine exposure. There is a need to develop effective vaccines against the virus that may gain genetic stability in the population. However, viruses isolated from the human body do not replicate well in chicken embryos, which constitutes a barrier to embryo-based vaccine production. In order to solve this problem, we want to get an adaptive mutation of chicken embryo of surface protein