本文综述了乳腺癌目前研究较为成熟和有肯定作用的生物学预后因子癌基因C-erbB-2、抑癌基因p53和肿瘤转移抑制基因nm23。它们均与乳腺癌的发生、发展、转移和复发密切相关,是乳腺癌的重要分子标志物和治疗靶。通过对生物学预后因子的研究,特别是多项生物学预后指标的联合检测和应用,并结合临床,从而更为有效、准确地估计乳腺癌患者的预后,并有助于指导乳腺癌的个体化治疗。 This review summarizes the biological prognostic factors C-erbB-2, p53, and nm23, a tumor suppressor gene, that are currently relatively well studied in breast cancer. They are all closely related to the occurrence, development, metastasis and recurrence of breast cancer and are important molecular markers and therapeutic targets for breast cancer. Through the study of biological prognostic factors, especially the joint detection and application of a number of biological prognostic indicators, combined with clinical, to more effectively and accurately estimate the prognosis of patients with breast cancer, and to help guide the individual breast cancer Treatment.