【摘 要】
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In eukaryotic cells, homologous recombination between DNA sequences residing in the chromosome and newly introduced DNA is commonly referred to as gene targeti
【机 构】
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Dupartment of Genetics, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA
【出 处】
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Progress in Natural Science
论文部分内容阅读
In eukaryotic cells, homologous recombination between DNA sequences residing in the chromosome and newly introduced DNA is commonly referred to as gene targeting.This emerging technology has proven to be a powerful means for precisely manipulating the mammalian genome. Gene targeting in totipotent murine embryonic stem (ES) cells can, theoretically, be used to generate mice of any desired genotype, thus aiding in the study of gene structure and function, as well as mammalian developmental biology. In addition, gene targeting also provides a
In eukaryotic cells, homologous recombination between DNA sequences residing in the chromosome and newly introduced DNA is commonly referred to as gene targeting. This emerging technology has proven to be a powerful means for precisely manipulating the mammalian genome. Gene targeting in totipotent murine embryonic stem ( ES) cells can, theoretically, be used to generate mice of any desired genotype, thus aiding in the study of gene structure and function, as well as mammalian developmental biology.
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