于1991年5月我科试用酮康唑片研磨成粉剂,局部应用治疗霉菌性角膜溃疡5例,收到良好疗效,报告如下。例1 田×男38岁住院号118504 左眼被木柴崩伤后红痛4天。全身检查正常。左眼混合性充血,角膜中央有一灰白色3×4mm 浅层溃疡。用庆大霉素治疗,2天后,溃疡加深,并扩大至5×6mm,角膜无光泽,怀疑霉菌感染。取溃疡面坏死组织培养,发现有霉菌丝及霉菌生长。停用庆大霉素,改用酮康唑粉局部涂用,1日3次。第2天,溃疡面脓液减少,第3天,溃疡边缘开始修复。10天后,上皮完全修复,浸润基本消退而出院。随访1年未复发 In May 1991, my department trial ketoconazole tablets ground into powder, topical application of fungal corneal ulcer in 5 cases, received a good effect, the report is as follows. Example 1 Tian × male 38-year-old hospital number 118504 left eye after the firewood collapse injury red pain for 4 days. The body check is normal. Mixed left eye congestion, central cornea has a white 3 × 4mm shallow ulcers. With gentamicin treatment, 2 days later, the ulcer deepened and expanded to 5 × 6mm, corneal matte, suspected mold infection. Take ulcer surface necrosis tissue culture, found that mold fungus and mold growth. Disable gentamicin, switch to ketoconazole powder topical application, 3 times on the 1st. On the second day, there was a reduction of pus in the ulcer area. On the third day, the edge of the ulcer began to be repaired. After 10 days, the epithelium was completely repaired and the infiltration basically disappeared and was discharged. One year follow-up did not recur