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速尿在体内通过与白蛋白结合达到作用部位而起作用,由于肾病综合征病人具有低白蛋白血症,其药效学和药物动力学发生相应变化,使速尿的利尿作用减弱。从理论上讲联合应用白蛋白可改善速尿的药物动力学。另外,白蛋白还可通过其他机制发挥利尿作用,如纠正低血容量、拮抗神经
Furosemide in the body by binding to albumin to reach the site of action, due to nephrotic syndrome patients with hypoalbuminemia, the pharmacodynamics and pharmacokinetics corresponding changes in furosemide diuretic effect weakened. In theory, the combination of albumin can improve the furosemide pharmacokinetics. In addition, albumin can also play a diuretic effect through other mechanisms, such as correcting low blood volume, antagonistic nerve