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目的 :模拟吸入高浓度贫铀 (depleteduranium ,DU)粉尘和 /或有DU弹片嵌入损伤 ,研究铀在机体内的动态变化和分布的主要器官 .方法 :将大鼠分为吸入粉尘组、单纯植片组、吸入 +植片组和正常对照组 ,在吸入高浓度的DU粉尘和/或在肌肉中植入DU片后第 1 ,3,7,1 5 ,2 0和 2 6日收集尿、血、肾、肺、肝、胸骨和卵巢样本 ,预处理后用激光荧光法测定铀含量 .结果 :在 1～ 2 6d的大部分时相点中 ,吸入组中铀浓度最大的器官依次是肺、卵巢和肾 ;单片组是肾、卵巢和胸骨 ;吸入 +植片组是肾、肺、卵巢和胸骨 ,大部分组织铀浓度均高于吸入组和单片组 .结论 :经吸入途径进入的铀分布的主要器官是肺、卵巢和肾 ,植入途径是肾、卵巢和胸骨 ,经两种途径进入的铀则显示出累积效应
OBJECTIVE: To simulate the inhalation of depleted uranium (DU) dust and / or interstitial damage of DU shells, and to study the dynamic changes and distribution of uranium in the body.Methods: The rats were divided into inhaled dust group, Group, inhalation + implant group and normal control group. Urine and blood were collected on days 1, 3, 7, 15, 20 and 26 after inhaling high concentration of DU dust and / or implanting DU into muscle , Kidneys, lungs, liver, sternum and ovary samples were collected and the uranium content was determined by laser fluorescence spectrometry after pretreatment.Results: In most of the time points from 1 to 26 days, the organs with the highest uranium concentration in inhalation group were lung, Ovary and kidney, monolithic group was kidney, ovary and sternum, and superoxide dismutase group was kidney, lung, ovary and sternum, and the uranium concentrations in most tissues were higher than that in inhalation group and monolithic group.Conclusion: The main organs of uranium distribution are lung, ovary and kidney, and the pathways of engraftment are kidney, ovary and sternum. Uranium entering through both pathways shows a cumulative effect