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Roth等报道了鸭疟原虫和恶性疟原虫中有谷氨酸脱氢酶,而且感染恶性疟原虫的红细胞的α-酮戊二酸含量要比未感染的约高4倍。红细胞中CO_2固定的其他途径也可能是α-酮戊二酸量增加。倘若能肯定由~(14)C标记的谷氨酸形成的~(14)C α-酮戊二酸代谢到~(14)CO_2,则表示有α-酮戊二酸脱氢酶存在于恶性疟原虫中,它至少是柠檬酸循环的一个功能性步骤。Homewood和Neame报道鸭疟原虫、伯氏疟原虫和诺氏疟原虫可固定CO_2,但是还未确证究竟CO_2是由虫本身固定的还是由宿主细胞固定。如能确定寄生于人体的恶性疟原虫能否固定相当量的CO_2则是非常有意义的。本文主要采用[1-~(14)C]谷
Roth et al. Reported that P. falciparum and P. falciparum have glutamate dehydrogenase, and the erythrocytes infected with P. falciparum have an about 4-fold higher alpha-ketoglutarate content than uninfected. Other ways of fixing CO 2 in red blood cells may also be an increase in the amount of α-ketoglutarate. If it can be confirmed that the ~ (14) C α-ketoglutarate formed by ~ (14) C-labeled glutamic acid is metabolized to ~ (14) CO_2, α-ketoglutarate dehydrogenase is present in malignant In malaria, it is at least a functional step of the citric acid cycle. Homewood and Neame reported that P. falciparum, P. berghei and P. nidulans can fix CO 2, but it has not been confirmed whether the CO 2 is immobilized by the insect itself or by the host cell. It is significant to determine if P. falciparum parasites in humans can fix a substantial amount of CO 2. This paper mainly uses [1- ~ (14) C] valley