猝死作为弥漫性胸膜间皮瘤的初发表现过去文献尚未见报道。本文报道1例。患者为44岁农村男性,过去体健,猝死当天早上诉有气促,此后很快出现心脏停搏,经心肺复苏抢救无效死亡。死亡后常规胸片显示右侧大量胸腔积液,右上外肺野见分叶状肿块。3小时后行尸体解剖,发现右胸膜腔内有约4L 浆液血性液体。右胸腔被分叶状坚硬的胸膜肿瘤所充填,肿块侵及胸壁及右肺胸膜下,并累及相对的区域淋巴结及膈顶,但无远处转 Sudden death as the initial manifestation of diffuse pleural mesothelioma has not been reported in the past. This article reported 1 case. The patient was a 44-year-old rural male. He used to be physically fit. There was shortness of breath on the day of early death, and soon afterwards, cardiac arrest occurred. He died after being rescued by cardiopulmonary resuscitation. After the death, the conventional chest radiograph showed a large amount of pleural effusion on the right side and a lobulated mass on the right upper and outer lung fields. An autopsy was performed 3 hours later and it was found that there was about 4 L of serous bloody fluid in the right pleural cavity. The right chest cavity is filled with lobulated hard pleural tumors. The tumors invade the chest wall and the right lung pleura, and involve the corresponding regional lymph nodes and domes, but no distant turn.