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目的提高对慢淋/幼淋细胞混合型白血病及其幼淋变的认识,探索氟达拉滨的疗效。方法报道1例慢淋/幼淋细胞混合型白血病发生的幼淋变及其治疗过程和氟达拉滨的应用,并进行文献复习。结果和结论(1)幼淋巴细胞性白血病是一类少见的恶性淋巴增殖性疾病,其中一部分由慢淋/幼淋细胞混合型白血病转变而来,形态学与原发幼淋巴细胞性白血病类似;(2)FMC7与SmIg双阳性及6号染色体异常可能与幼淋变病例的临床和血液学特征密切相关;(3)氟达拉滨可诱导慢淋/幼淋细胞混合型白血病幼淋变达完全缓解。
OBJECTIVE To improve the understanding of mixed leukemia and juvenile leukemia and explore the efficacy of fludarabine. Methods One case of mixed leukemia with chronic lymphocytic leukemia and its treatment and the application of fludarabine were reported and reviewed. RESULTS AND CONCLUSION: (1) Lymphoblastic leukemia is a rare malignant lymphoproliferative disease, some of which is caused by mixed leukemia of leaching / lymphocytic leukemia. Its morphology is similar to that of primary lymphocytic leukemia. (2) The positive of FMC7 and SmIg and the abnormality of chromosome 6 may be closely related to the clinical and hematological characteristics of juvenile lymphoid leukemia patients. (3) Fludarabine can induce the juvenile leaching of lean and lymphocytic leukemia complete relief.