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采用立体选择性分析方法测定了3，4－甲撑二氧去氧麻黄碱在大鼠和小鼠体内0～96h的排泄量。结果表明药物及其代谢物对映体呈现立体选择性的代谢。药物的S－（＋）－对映体在N－脱甲基代谢途径中占优势（S／R=1．61），R－（－）-对映体则在O-脱烃基代谢途径中占主导地位（R／S＝1.28）。毒性大的S－（＋）－对映体代谢较慢；该药物的主体选择性代谢具有种属差异。
The 3,4-methylenedioxmephedrine excretion from 0 to 96 hours in rats and mice was determined by stereoselective analysis. The results show that the enantiomers of the drug and its metabolites exhibit stereoselective metabolism. The S - (+) - enantiomer of the drug predominates in the N-demethylation pathway (S / R = 1.61) and the R - (-) - enantiomer is in the O-dealkylation pathway Dominates (R / S = 1.28). The more toxic S - (+) - enantiomers are metabolized slowly; the subject’s selective metabolism of the drug has species differences.