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目的研究黄芪多糖对小鼠应激能力和血中超氧化物歧化酶(SOD)、丙二醛(MDA)水平的影响,进而探讨黄芪多糖的抗衰老作用机制。方法取小鼠随机分为黄芪多糖大、小剂量组和对照组,然后行小鼠游泳耐疲劳、耐寒冷、常压耐缺氧实验,测定并比较黄芪多糖组与对照组血清MDA含量和SOD的活性。结果黄芪多糖可以提高小鼠在低温环境下的耐寒能力,降低死亡率;延长小鼠力竭游泳时间,提高抗疲劳能力;延长小鼠常压耐缺氧时间,提高耐缺氧能力;同时使血清SOD活力明显升高、MDA含量明显降低,与对照组相比,差异有统计学意义(P<0.01)。结论本研究表明,黄芪多糖具有良好的体内抗氧化作用,可以延缓衰老。
Objective To study the effect of astragalus polysaccharides on the stress ability and the levels of superoxide dismutase (SOD) and malondialdehyde (MDA) in mice, and then explore the anti-aging mechanism of Astragalus polysaccharides. Methods The mice were randomly divided into large and small doses of astragalus polysaccharide group and control group, and then swim fatigue resistance, cold tolerance, hypoxia-tolerance test in mice, the serum MDA content and SOD Activity. Results Astragalus polysaccharide can improve the cold resistance of mice in low temperature environment, reduce the mortality rate; prolong the exhaustive swimming time in mice and improve the anti-fatigue ability; prolong the pressure-tolerant time of hypoxia in mice to improve hypoxia tolerance; Serum SOD activity was significantly increased, MDA content was significantly lower, compared with the control group, the difference was statistically significant (P <0.01). Conclusion This study shows that APS has a good antioxidant activity in vivo and can delay aging.