论文部分内容阅读
雷公藤对类风湿性关节炎、系统性红斑狼疮和肾病等自身免疫性疾病的临床疗效显著,但其严重的毒副作用限制了临床应用与推广。有毒中药一直是中药炮制研究的重点,古云“有毒宜制”。以雷公藤和炮制为主题,经检索中国知网和SciFimler等国内外数据库,发现雷公藤炮制研究基本为国内报道。本文就近30年来有关雷公藤的炮制研究进行综述,较全面、系統地总结了炮制对雷公藤毒性、药效及其化学成分的影响,以期为雷公藤的深人炮制研究、新药开发及其临床应用安全性和有效性的提高提供参考。
Tripterygium for rheumatoid arthritis, systemic lupus erythematosus and nephropathy and other autoimmune diseases, the clinical efficacy of significant, but its serious side effects limit the clinical application and promotion. Toxic medicine has always been the focus of traditional Chinese medicine concocted, ancient cloud “poisonous system.” Taking Tripterygium wilfordii and Processed as the theme, after searching CNKI and SciFimler and other domestic and foreign databases, it was found that the research of TWG processing was basically reported in China. In this paper, we summarize the processing of Tripterygium wilfordii in the past 30 years, and summarize the effects of processing on the toxicity, pharmacodynamics and chemical composition of Tripterygium wilfordii in a comprehensive and systematic way, in order to deepen the processing research, new drug development and clinical Application security and effectiveness to provide reference.