AIM To compare the effects of extract F of red-rootedSalvia(EFRRS)on mucosal lesions of gastric corpus andantrum induced by hemorrhagic shock and reperfusion inrats.METHODS The rats were subject to hemorrhagic shockand followed by reperfusion,and were divided randomlyinto two groups.Group 1 received saline,and group 2received EFRRS intravenously.The index of gastricmucosal lesions(IGML)was expressed as the percentageof lesional area in the corpus or antrum.The degree ofgastric mucosal lesions(DGML)was catalogued grade 0,1,2 and 3.The concentrations of prostaglandins(PGs)were measured by radioimmunoassay.The concentrationof MDA was measured according to the procedures ofAsakawa.The activity of SOD was measured by thebiochemical way.The growth rates or inhibitory rates ofabove-mentioned parametes were calculated.PESULTS As compared with IGML(%),grade 3 damage(%)and MDA content(nmol/g tissue)of gastric antrumwhich were respectively 7.96±0.59,34.86±4.96 and156.98±16.12,those of gastric corpus which wererespectively 23.18±6.82,58.44±9.07 and 230.56±19.37increased markedly(P<0.01),whereas the grade 0damage,grade 1 damage,the concentrations of PGE_2 andPGI_2(pg/mg tissue),the ratio of PGI_2/TXA_2 and theactivity of SOD(U/g tissue)of corpus which wererespectively 3.01±1.01,8.35±1.95,540.48±182.78,714.38±123.74,17.38±5.93 and 134.29±13.35 weremarkedly lower than those of antrum which wererespectively 13.92±2.25,26.78±6.06,2218.56±433.12,2531.76±492.35,43.46±8.51 and 187.45±17.67(P<0.01)after hemorrhagic shock and reperfusion.Afterintravenous EFRRS,the growth rates(%)of grade 0damage,grade 1 damage,the concentrations of PGE_2 andPGI_2, the ratio of PGI_2/TXA_2 and the activity of SOD ofcorpus which were respectively 632.56,308.62,40.75, 74.75,92.29 and 122.25 were higher than those in antrumwhich were respectively 104.89,58.40,11.12,56.58,30.65 and 82.64,whereas the inhibitory rates(%)ofIGML,grade 3 damage and MDA content of gastric corpuswere 82.93,65.32 and 59.09,being higher than those ofgastric antrum which were 76.64,53.18 and 42.37.CONCLUSION After hemorrhagic shock-reperfusion,thegastric mucosal lesions in the corpus were more severethan those in the antrum,which were related not only tothe different distribution of endogenous PGs in themucosa,but also to the different ability of anti-oxidationof the mucosa.The protective effect of EFRRS on thegastric mucosa in the corpus was more evident than thatin the antrum,which was related to higher growth degreeof PGs contents and anti-oxitative ability in gastric corpusafter administration of EFRRS. AIM To compare the effects of extract F of red-rooted Salvia (EFRRS) on mucosal lesions of gastric corpus andantrum induced by hemorrhagic shock and reperfusion in rats. METHODS The rats were subject to hemorrhagic shockand followed by reperfusion, and were divided randomlyinto two groups. Group 1 received saline, and group 2received EFRRS intravenously. The index of gastric mucosal lesions (IGML) was expressed as the percentageof lesional area in the corpus or antrum. Degree of gastric mucosal lesions (DGML) was catalogued grades 0,1,2 and 3. The concentrations of prostaglandins (PGs) were measured by radioimmunoassay. The concentration of MDA was measured according to the procedures of Asakawa. The activity of SOD was measured by the biochemical way. The growth rates or inhibitory rates ofabove-mentioned parametes were calculated. PESULTS As compared with IGML (%), grade 3 damage (%) and MDA content (nmol / g tissue) of gastric antrum were respectively 7.96 ± 0.59, 34.86 ± 4.96 and 156.98 ± 16.12, those of gastric The levels of damage, the concentrations of PGE_2 and PGI_2 (pg / mg tissue), the ratio of PGI_2 / TXA_2 and pGI_2 (pg / mg of tissue) theactivity of SOD (U / g tissue) of corpus which wererespectively 3.01 ± 1.01,8.35 ± 1.95,540.48 ± 182.78,714.38 ± 123.74,17.38 ± 5.93 and 134.29 ± 13.35 weremarkedly lower than those of antrum which wererespectively 13.92 ± 2.25,26.78 ± The growth rates (%) of grade 0damage, grade 1 damage, the concentrations of PGE_2 and PGI 2 (P <0.01) , the ratio of PGI_2 / TXA_2 and the activity of SOD of corpus which were respectively 632.56, 308.62, 40.75, 74.75, 92.29 and 122.25 were higher than those in antrum were respectively 104.89, 58.40, 11.12, 56.58, 30.65 and 82.64, rates (%) of IGML, grade 3 damage and MDA content of gastric corpuswere 82.93, 65.32 an d 59.09, being higher than those of gastric antrum which were 76.64, 53.18 and 42.37.CONCLUSION After hemorrhagic shock-reperfusion, the gastric mucosal lesions in the corpus were more severe than those in the antrum, which were related not only tothe different distribution of endogenous PGs in themucosa, but also to the different ability of anti-oxidation of the mucosa. the protective effect of EFRRS on the gastric mucosa in the corpus was more evident than that in the antrum, which was related to higher growth degree of PGs contents and anti-oxitative ability in gastric corpus after administration of EFRRS .