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目的研究匹多莫德注射液的药物动力学。方法 6只家兔,以100 mg·kg-1的剂量耳缘静脉注射匹多莫德注射液,给药前及给药后不同时间定时采取血样;以HPLC法测定血浆样品中匹多莫德的浓度,并对该制剂的药物动力学特征进行评价。结果家兔静脉注射给予匹多莫德后,匹多莫德的k为(1.2±0.2)h-1,t1/2为(0.6±0.1)h,AUC0-t为(240.4±31.0)mg·h·L-1,AUC0-∞为(262.2±32.6)mg·h·L-1,V为(1.3±0.8)L,CL为(1.4±0.7)L·h-1。结论该研究可为匹多莫德注射液的临床应用提供一定的科学依据。
Objective To study the pharmacokinetics of pidotimod injection. Methods Six rabbits were injected with pidotimod at a dose of 100 mg · kg-1, and the blood samples were collected before administration and at different time points after administration. The plasma concentrations of podolactone The pharmacokinetic profile of this formulation was evaluated. Results After intravenous injection of pidotimod to rabbits, the podopod’s k was (1.2 ± 0.2) h-1, t1 / 2 was (0.6 ± 0.1) h and AUC0-t was (240.4 ± 31.0) mg · h · L-1, AUC0-∞ was (262.2 ± 32.6) mg · h · L-1, V was (1.3 ± 0.8) L and CL was (1.4 ± 0.7) L · h-1. Conclusion This study may provide a scientific basis for the clinical application of pidotimod injection.