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目的 分析轻度胃肠炎伴良性婴幼儿惊厥 (BICE)的临床特点。方法 1999年 7月至 2003年 3月,对北京中日友好医院儿科 8例年龄 3~36个月的轻度胃肠炎伴惊厥患儿进行临床观察和出院后 18个月以上的随访。结果 8例发病年龄(14 0±5 9)个月,冬季发病 4例, 3d内发生惊厥 6例,全身性发作 7例,有早期频繁发作 5例,一次病程中惊厥平均发作 2 4次。发作间期EEG背景正常,脑影像学、血生化及脑脊液检查正常。惊厥停止后未行抗疒间治疗, 3例复发,复发≤2次,病程少于 1年。全部病例无癫疒间和热性惊厥家族史,精神运动发育正常。结论 本组BICE具有以下特点: (1) 1 ~2岁高发,冬季多发,无家族史; (2)无热惊厥于病程的 1 ~5d发生,全身性发作为主,早期频繁发作多见,无脱水及酸中毒; 930血电解质、脑脊液、脑影像学和发作间期脑电图正常; (4)部分病例可复发,次数≤2次,病程少于 1年,预后好。
Objective To analyze the clinical features of mild gastroenteritis with benign infantile convulsion (BICE). Methods From July 1999 to March 2003, 8 children with mild gastroenteritis and convulsion aged 3-36 months in pediatric department of Sino-Japanese Friendship Hospital of Beijing were followed up for more than 18 months after discharge. Results The age of onset was (14 0 ± 5 9) months in 8 cases, 4 in winter, 6 in convulsions in 3d and 7 in general. There were 5 cases with frequent seizures in early stage and 24 cases with seizures in one course. Interictal EEG background normal, brain imaging, blood biochemistry and cerebrospinal fluid examination was normal. Seizures stopped without anti-tuberculosis treatment, 3 cases of relapse, relapse ≤ 2 times, duration of less than 1 year. All cases without epilepsy and febrile seizures family history, mental motor development is normal. Conclusions This group of BICE has the following characteristics: (1) high incidence of 1 ~ 2 years old, multiple seasons in winter, no family history; (2) no febrile seizures occur in the course of 1 ~ 5d, systemic attacks, frequent early episodes, No dehydration and acidosis; 930 blood electrolytes, cerebrospinal fluid, brain imaging and interictal EEG normal; (4) some cases of recurrent, the number of ≤ 2 times, duration less than 1 year, the prognosis is good.