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目的:研究MMP-9在涎腺良、恶性肿瘤组织和涎腺炎症疾病中的表达特征及临床指导意义。方法:免疫组化和明胶酶谱法检测MMP-9在涎腺良、恶性肿瘤组织、炎症组织和正常涎腺组织中的表达。结果:MMP-9在涎腺良、恶性肿瘤组织、炎症组织和正常涎腺组织中均有表达,并且在恶性肿瘤中的表达显著高于其它3组(P<0.05);涎腺炎症组表达又显著高于良性肿瘤组(P<0.05),良性肿瘤组表达显著高于正常组织(P<0.05)。结论:MMP-9蛋白表达强度与涎腺肿瘤的恶性程度呈正相关;并且涎腺炎症组织中MMP-9表达高于涎腺良性肿瘤,说明MMP-9不仅与肿瘤的侵袭和转移相关,还有可能与肿瘤的发生存在一定的联系。
Objective: To investigate the expression and clinical significance of MMP-9 in benign and malignant salivary glands and salivary gland inflammatory diseases. Methods: The expressions of MMP-9 in benign and malignant salivary gland tissues, inflammatory tissues and normal salivary glands were detected by immunohistochemistry and gelatin zymography. Results: The expression of MMP-9 in benign and malignant salivary gland tissues, inflammatory tissues and normal salivary glands was significantly higher than that in the other three groups (P <0.05). The expression of MMP-9 in salivary gland inflammation group (P <0.05), and the expression in benign tumors was significantly higher than that in normal tissues (P <0.05). Conclusion: The expression of MMP-9 protein is positively correlated with the malignant degree of salivary gland tumor, and the expression of MMP-9 in salivary gland inflammation tissue is higher than that of salivary gland benign tumor, indicating that MMP-9 is not only related to tumor invasion and metastasis, There may be a certain relationship with the occurrence of cancer.