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患者,女,34岁。因少语、被害感、易激惹15年,于1991年7月5日入院。入院检查:内科及神经系统未发现异常,精神检查有幻听,被害妄想、情绪低、有自杀观念。入院诊断为“精神分裂症”。入院时白细胞为3.35×10~9/L,多核0.69,带核0.06,淋巴0.24、单核0.01。给予氯丙嗪150mg/日合并电休克治疗,精神症状无明显改善,于入院后第十天改服氯氮平治疗,始量25mg每日两次,逐渐加量至250mg/日,治疗四月后幻觉、妄想消失,情绪改善,除流涎外无其他不适。氯氮平治疗期间复查白细胞在4.5×10~9/L～6.5×10~9/L
Patient, female, 34 years old. Insomnia, victimized, irritable 15 years, admitted to hospital on July 5, 1991. Admission examination: No abnormalities in internal medicine and nervous system, auditory hallucinations, delusions of murder, low mood and suicidal ideation. Admission diagnosed as “schizophrenia.” Admission leukocyte 3.35 × 10 ~ 9 / L, multi-core 0.69, with nuclear 0.06, lymph 0.24, mononuclear 0.01. Give chlorpromazine 150mg / day combined with electroshock therapy, no significant improvement in mental symptoms, change clozapine treatment on the tenth day after admission, the initial amount of 25mg twice daily, gradually added to 250mg / day, the treatment of April After the illusion, paranoia disappeared, mood improvement, no other discomfort except drooling. Clozapine treatment during the review of leukocytes 4.5 × 10 ~ 9 / L ~ 6.5 × 10 ~ 9 / L