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内生致热原(Endogenous Pyrogen, EP)是在1948年由Beeson首先发现的。至今,EP在发热研究领域中一直倍受重视。这不仅是由于EP在发热发病学中占有重要的地位,它是发热的基本“信息”分子,而且近年来对EP作用的研究已扩展到与感染、类症以及免疫性疾病反应等有关的领域。目前认为EP是一组物质的总称,其中包括白细胞致热原(LP),干扰素(IFN),肿瘤坏死因子(TNF)、巨噬细胞类症蛋白-1(MIP-1)等。大量资料报道LP即白细胞介素1(IL-1)。由此可见:EP是一件较复杂且作用广,值得深入研究的细胞因子。本文对EP研究的最新进展作一简要综述。
Endogenous Pyrogen (EP) was first discovered by Beeson in 1948. To date, EP has drawn great attention in the field of fever research. This is not only because EP plays an important role in the pathogenesis of fever, it is the basic “information” molecule of fever, and research on the role of EP in recent years has been extended to related fields such as infection, xenograft and immune disease reaction . EP is currently considered a group of substances in general, including leukocyte pyrogen (IFN), tumor necrosis factor (TNF), macrophage disease protein-1 (MIP-1) and so on. A large number of reports LP that interleukin 1 (IL-1). This shows that: EP is a more complex and broad-based, worthy of further study of cytokines. This article gives a brief overview of the latest progress of EP research.