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内皮细胞损伤导致的血管内皮功能障碍目前被认为是诱发许多心脑血管疾病的共同环节,其中血管内皮舒张功能的受损是血管内皮功能障碍的重要特征之一。高血压是引起动脉粥样硬化和血管重塑的重要危险因素之一,高血压与内皮舒张功能障碍之间存在密切关系。本文就高血压导致内皮舒张功能障碍的表现和临床意义,高血压导致内皮舒张功能障碍的病理机制,以及降压药物对血管内皮的保护作用进行综述。
Vascular endothelial dysfunction caused by endothelial cell injury is currently considered to be common in many cardiovascular and cerebrovascular diseases. Among them, the impairment of vascular endothelial relaxation is one of the most important features of vascular endothelial dysfunction. Hypertension is one of the important risk factors of atherosclerosis and vascular remodeling. There is a close relationship between hypertension and endothelial dysfunction. In this paper, the performance and clinical significance of hypertension leading to endothelial dysfunction, the pathological mechanism of hypertension leading to endothelial dysfunction and the protective effect of antihypertensive drugs on vascular endothelial are reviewed.