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目的:分析依达拉奉联合阿司匹林治疗进展性脑梗死的治疗效果。方法:将2012年2月至2016年2月于迁安市人民医院接受治疗的148例进展性脑梗死患者,根据用药的不同,随机平均分为对照组和治疗组,对照组给予常规治疗+阿司匹林治疗,治疗组则给予常规治疗+阿司匹林+依达拉奉治疗,连续治疗10 d,比较两组治疗前后神经功能缺损评分、临床疗效、用药后副作用、凝血功能指标变化。结果:所有患者治疗后神经功能缺损评分(NIHSS)评分均低于治疗前(P<0.01),治疗组治疗总有效率89.19%,而对照组治疗总有效率47.30%,两组比较,差异具有统计学ujy意义(P<0.01);两组患者均出现1例消化道出血和1例泌尿系统出血,总发生率均为2.7%;两组患者凝血指标治疗前后无显著性变化(P>0.05),且两组之间无显著性差异(P>0.05)。结论:依达拉奉联合阿斯匹林治疗进展性脑梗死疗效显著,副作用小,可用于临床治疗。
Objective: To analyze the therapeutic effect of edaravone combined with aspirin in patients with advanced cerebral infarction. Methods: From February 2012 to February 2016, 148 patients with progressive cerebral infarction who were treated in Qian’an People’s Hospital were randomly divided into control group and treatment group according to the different medication. The control group was given routine treatment + Aspirin treatment, the treatment group was given conventional treatment + aspirin + edaravone treatment, continuous treatment of 10 d, before and after treatment, neurological deficit score, clinical efficacy, side effects after treatment, changes in coagulation function. Results: The NIHSS scores of all patients after treatment were lower than those before treatment (P <0.01). The total effective rate was 89.19% in the treatment group and 47.30% in the control group. There was significant difference between the two groups (P <0.01). One case of gastrointestinal bleeding and one case of urinary system hemorrhage occurred in both groups, with a total incidence of 2.7%. There was no significant difference in coagulation index between the two groups before and after treatment (P> 0.05 ), And there was no significant difference between the two groups (P> 0.05). Conclusion: Edaravone combined with aspirin has a significant curative effect in treating progressive cerebral infarction with small side effects and can be used in clinical treatment.