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目的 探讨染色体异常在遗传咨询病人中的发生情况。方法 取受检者外周血进行淋巴细胞培养 ,常规收获制片 ,G显带处理 ,显微镜下进行核型分析。结果 在 8880例病人中共检出染色体异常 373例 ,染色体异常检出率为 4 2 0 % ,其中平衡易位 131例 (35 12 % ) ,罗伯逊易位 31例 (8 31% ) ,倒位 12例 (3 2 2 % ) ,性染色体异常 10 8例 (2 8 95 % ) ,染色体不平衡 91例 (2 4 40 % )。结论 妇产科许多疾病与染色体异常有关 ,对这些病人进行染色体检查很有必要。
Objective To investigate the occurrence of chromosomal abnormalities in genetic counseling patients. Methods Peripheral blood was collected from the subjects for lymphocyte culture, conventional harvesting and G-banding, and karyotype analysis was performed under a microscope. Results A total of 373 chromosomal abnormalities were detected in 8,880 patients. The detection rate of chromosomal abnormalities was 42.0%, of which 131 were balanced (35 12%), 31 (8 31%) were Robertson translocation, and 12 Cases (32.2%), 108 cases of chromosomal abnormalities (28.5%), 91 cases of chromosomal imbalance (240%). Conclusion Many obstetrics and gynecology diseases are related to chromosomal abnormalities. It is necessary to carry out chromosome examination in these patients.