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目的探讨亚急性甲状腺炎患者采用小剂量泼尼松治疗的临床效果。方法所选研究对象为2015年6月至2016年6月铁岭县中心医院收治的88例亚急性甲状腺炎患者,按照1:1比例将其随机分为研究组(小剂量泼尼松)与对照组(常规大剂量泼尼松),各44例。比较两组患者治疗效果、临床症状消失时间及不良反应发生情况。结果研究组、对照组患者治疗的总有效率分别为97.7%、95.5%,差异无统计学意义(P>0.05);两组患者甲状腺疼痛消退时间、发热消退时间、甲状腺触痛消失时间比较,差异均无统计学意义(均P>0.05);研究组、对照组患者不良反应发生率分别为4.5%、18.2%,差异有统计学意义(P<0.05)。结论在亚急性甲状腺炎患者的临床治疗过程中,采用小剂量泼尼松治疗,能获得与常规大剂量泼尼松治疗相似的临床效果,且能减少不良反应发生,安全可靠。
Objective To investigate the clinical effect of low-dose prednisone treatment in patients with subacute thyroiditis. Methods Selected subjects were 88 patients with subacute thyroiditis admitted to the Central Hospital of Tieling from June 2015 to June 2016. The patients were randomly divided into study group (low-dose prednisone) and control Group (conventional high-dose prednisone), each 44 cases. The treatment effect, the disappearance of clinical symptoms and the incidence of adverse reactions were compared between the two groups. Results The total effective rate of treatment in study group and control group was 97.7% and 95.5%, respectively, with no significant difference (P> 0.05). Compared with the disappearance time of thyroid pain, There was no significant difference between the two groups (all P> 0.05). The incidences of adverse reactions in study group and control group were 4.5% and 18.2%, respectively, with significant differences (P <0.05). Conclusions In the course of clinical treatment of patients with subacute thyroiditis, low-dose prednisone treatment can achieve similar clinical effects as conventional high-dose prednisone treatment, and can reduce adverse reactions and is safe and reliable.