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人类免疫缺陷症病毒(HIV)MN、SF-2和Ⅲ B株是广泛用于制备疫苗的三株病毒株.1型HIV(HIV-1)糖蛋白(gP)120和gp41在病毒感染过程中起重要作用,是HIV 疫苗的首选组份.本文报道了美国圣路易斯大学艾滋病疫苗评价中心进行的HIV-1重组gp120疫苗的安全性与免疫原性的临床试验结果.
Human immunodeficiency virus (HIV) strains MN, SF-2 and ΠΒ are three strains of viruses that are widely used to prepare vaccines. Type 1 HIV (1) glycoproteins (gP) 120 and gp41, Plays an important role as the first choice of HIV vaccine.This paper reports the results of clinical trials on the safety and immunogenicity of HIV-1 recombinant gp120 vaccine conducted by the AIDS Vaccine Evaluation Center of St. Louis University.