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肾脏是尿酸排泄的主要器官。体内尿酸70%由肾脏排出,其余30%经胆管和肠道排出。由于嘌呤代谢紊乱使血尿酸生成过多,或由于肾脏病变排泄尿酸减少,均可引起高尿酸血症(HUA)。慢性肾脏病(CKD)肾功能不全是继发性HUA的常见原因。CKD患者HUA的特点临床观察到CKD患者发生HUA时血清肌酐升高和血尿酸升高往往不成比例,是由于机体能通过
Kidney is uric acid excretion of the main organs. 70% of body uric acid excreted by the kidneys, the remaining 30% of the bile duct and intestinal discharge. Hyperuricemia (HUA) can occur as a result of hyperuricemia due to disorders of purine metabolism, or loss of uric acid due to renal disease. Chronic kidney disease (CKD) Renal insufficiency is a common cause of secondary HUA. The characteristics of HUA CKD patients clinically observed in CKD patients with HUA serum creatinine rise and elevated serum uric acid often is not proportional because the body can pass