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目的探讨辛伐他汀对脓毒症大鼠心肌的保护作用。方法选择清洁级WISTAR大鼠80只,随机分为两组,研究组和对照组,各40只。通过肠缺血-再灌注联合盲肠结扎穿孔法建立大鼠脓毒症模型。模型制作成功后,给予研究组尾静脉注射辛伐他汀20mg/kg+0.9%氯化钠溶液2ml/kg。对照组给予0.9%氯化钠溶液20ml/kg。比较两组大鼠治疗前、治疗5h、10h肌酸激酶同工酶(CK-MB)及一氧化氮(NO)水平。结果 CK-MB时间和方法有交互作用(P<0.05);时间间比较,差异有统计学意义(P<0.05);组间比较,差异有统计学意义(P<0.05)。NO时间和方法有交互作用(P<0.05);时间间比较,差异有统计学意义(P<0.05);组间比较,差异有统计学意义(P<0.05)。治疗5、10h研究组CK-MB、NO水平高于对照组,差异有统计学意义(P<0.05)。结论辛伐他汀对保护脓毒症大鼠心肌细胞有一定价值,能减轻炎性反应。
Objective To investigate the protective effects of simvastatin on myocardium of septic rats. Methods Eighty clean WISTAR rats were randomly divided into two groups, study group and control group, 40 in each. Rat sepsis model was established by intestinal ischemia-reperfusion combined with cecal ligation and perforation. After successful model making, the study group was given intravenous injection of simvastatin 20 mg / kg + 0.9% sodium chloride solution 2 ml / kg. The control group was given 0.9% sodium chloride solution 20ml / kg. The levels of creatine kinase (CK) MB and nitric oxide (NO) in the two groups before treatment, 5h and 10h after treatment were compared. Results There was an interaction between CK-MB time and the method (P <0.05). There was significant difference in time between the two groups (P <0.05). There was significant difference between the two groups (P <0.05). There was interaction between NO time and method (P <0.05). There was significant difference in time between two groups (P <0.05). There was significant difference between two groups (P <0.05). The levels of CK-MB and NO in the treatment group for 5 and 10h were significantly higher than those in the control group (P <0.05). Conclusion Simvastatin has certain value in protecting cardiomyocytes of septic rats and can reduce the inflammatory reaction.