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目的:对脑卒中后抑郁症患者给予乌灵胶囊联合抗抑郁药治疗,观察其临床疗效及对神经功能的影响。方法:选取2011年6月—2015年6月医院收治的脑卒中后抑郁症患者78例,按照治疗方法不同将其分为观察组与对照组各39例。对照组患者采用常规抗抑郁药治疗,观察组在给予常规抗抑郁药治疗基础上外加给予乌灵胶囊治疗。治疗后对两组患者临床疗效进行比较,并对两组患者的神经功能改善情况进行观察比较。结果:治疗后,观察组治疗总有效率为94.9%,对照组治疗总有效率为79.5%,观察组与对照组比较明显提高,差异具有显著性(P<0.05);与治疗前比较,观察组治疗1周、2周、3周、4周后汉密尔顿抑郁量表(HAMD)评分均明显降低,对照组治疗1周后无明显变化,治疗2周、3周、4周后HAMD评分明显降低,差异具有显著性(P<0.05),其中观察组改善程度与对照组改善程度比较更显著(P<0.05)。与治疗前比较,观察组与对照组治疗后日常生活能力评估量表(BI)评分均明显提高,差异具有显著性(P<0.05),其中观察组较对照组改善更显著(P<0.05)。结论:对脑卒中后抑郁症患者给予乌灵胶囊联合抗抑郁药治疗具有良好的临床疗效,可显著改善患者神经功能及日常生活能力,值得临床推广应用。
Objective: To treat patients with post-stroke depression with Wuling capsules combined with antidepressants and to observe their clinical effects and their effects on neurological function. Methods: Seventy-eight patients with post-stroke depression who were admitted to our hospital from June 2011 to June 2015 were selected and divided into observation group (39 cases) and control group (39 cases) according to different treatment methods. Patients in the control group were treated with conventional antidepressants. The observation group was treated with Wuling capsules on the basis of conventional antidepressants. After treatment, the clinical efficacy of the two groups were compared, and the improvement of neurological function in both groups was observed and compared. Results: After treatment, the total effective rate of the observation group was 94.9%, the total effective rate of the control group was 79.5%, the observation group and the control group were significantly improved (P <0.05); compared with before treatment, The Hamilton Depression Rating Scale (HAMD) score was significantly lower in the treatment group at 1 week, 2 weeks, 3 weeks and 4 weeks. There was no significant change in the control group after 1 week of treatment. The HAMD scores at 2 weeks, 3 weeks and 4 weeks after treatment were significantly lower , The difference was significant (P <0.05). The improvement degree in the observation group was more significant than that in the control group (P <0.05). Compared with those before treatment, the daily living ability assessment scale (BI) of the observation group and the control group were significantly improved (P <0.05), and the observation group improved more significantly than the control group (P <0.05) . Conclusion: The treatment of depressive patients after stroke with Wuling Capsule combined with antidepressant has a good clinical efficacy, can significantly improve the patient’s neurological function and daily living ability, worthy of clinical promotion and application.