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目的探讨血液灌流(HP)联合血液透析(HD)治疗尿毒症的疗效。方法将69例患者随机分为联合组(36例)和对照组(33例),联合组行血液灌流及血液透析,对照组行常规血液透析。治疗前、后观察β2-微球蛋白(β2-MG)、甲状旁腺激素(PTH)、尿素氮(Bun)、肌酐(Cr)、血红蛋白(Hb)等指标。结果联合组患者的PTH、β2-MG清除率显著高于对照组,经分析有统计学意义(P<0.05)。结论血液灌流联合血液透析治疗能有效清除尿毒症患者体内的PTH、β2-MG等中分子物质,改善患者的生活质量,具有较好的应用价值。
Objective To investigate the therapeutic effect of hemoperfusion (HP) combined with hemodialysis (HD) on uremia. Methods Sixty-nine patients were randomly divided into combined group (36 cases) and control group (33 cases). The combined group was subjected to hemoperfusion and hemodialysis. The control group received routine hemodialysis. Before and after treatment, β2-microglobulin, PTH, Bun, creatinine and Hb were measured. Results The clearance rate of PTH and β2-MG in the combined group was significantly higher than that in the control group, which was statistically significant (P <0.05). Conclusion Hemoperfusion combined with hemodialysis can effectively remove the PTH, β2-MG and other molecular substances in patients with uremia, improve the quality of life of patients with good value.