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为了解沥青工血清ｒａｓＰ２１癌蛋白水平，从分子水平阐明毒作用，用ＷｅｓｔｅｒｎＢｌｏｔｉｎｇ法对２４名沥青工和１２正常对照组血清Ｐ２１进行分子流行病学调查研究。结果：沥青工Ｐ２１均值（３５５８．７）明显高于对照（１２７０．７），差异有显著性；接触组沥青工中按工龄分组和按是否吸烟分组进行比较，均未发现组间Ｐ２１的显著性差异。此结果提示，煤焦沥青可能使机体癌蛋白Ｐ２１水平提高
To understand the serum level of rasP21 oncoprotein, the molecular mechanism of rasP21 oncoprotein was elucidated at molecular level. The molecular epidemiology of serum P21 in 24 asphaltene and 12 normal controls was investigated by Western Blotting. Results: The average P21 (3558.7) of asphaltene workers was significantly higher than that of the control (1270.7), the difference was significant. P21 was not significantly different between the two groups in terms of age group and smoking group Sex differences. This result suggests that coal tar pitch may increase the level of the body’s oncoprotein P21