美国洛杉机医学中心肿瘤外科对18例实体瘤患者静脉和肝动脉内注射阿霉素30mg/M~2,1.5～5小时后,趁手术检测后各种组织阿霉素含量。测定结果发现正常肝组织中含量最高(2.3～19.8μg/g),淋巴结次之(1.46～3.06μg/g),再次为肌肉和骨髓(0.19～1.63μg/g),脂肪和皮肤最低(0.2μg/g)。肿瘤组织中(如若无坏死或出血者)浓度与肝中浓度相似(1.1～9.2μg/g)。6例肝脏恶性肿瘤病人静脉注射阿霉素后,血清浓度持续时间延长。阿霉素直接注入肝动脉与周围静 In the tumor surgery of the Los Angeles Medical Center in the United States, doxorubicin was injected into the veins and hepatic arteries of 18 patients with solid tumors and 30 mg/M~2 for 1.5 to 5 hours. The results showed that the highest levels were found in normal liver tissues (2.3 to 19.8 μg/g), followed by lymph nodes (1.46 to 3.06 μg/g), again muscle and bone marrow (0.19 to 1.63 μg/g), and fat and skin were the lowest (0.2 Μg/g). The tumor tissue (if no necrosis or hemorrhage) was similar to the liver (1.1 to 9.2 μg/g). Six patients with hepatic malignancy received intravenous doxorubicin and serum concentrations continued to increase. Adriamycin injected directly into the hepatic artery and surrounding static