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除BMP-1外BMPs均属于转化生长因子β超家族,至少包括20个成员。其最初是作为一种可在异位诱导骨和软骨形成的蛋白质被发现的,它是一种具有多种功能的细胞因子家族,不仅存在于骨和软骨中,还存在于其他组织中(如肝、肺、肾、心、肠道、肢体及神经系统等)。几乎胚胎发育的关键步骤都受到了BMPs的调控,并参与调控多种组织和器官的形态发生。此外,研究发现。BMPs不仅与骨肿瘤疾病的发生、发展密切关系,而且在一
In addition to BMP-1, BMPs belong to the transforming growth factor β superfamily, including at least 20 members. Originally discovered as a protein that can be used to ectopically induce bone and cartilage formation, it is a family of cytokines with multiple functions, not only in bone and cartilage, but also in other tissues (such as Liver, lung, kidney, heart, intestine, limbs and nervous system, etc.) Almost all key steps in embryonic development have been regulated by BMPs and are involved in the regulation of morphogenesis in a variety of tissues and organs. In addition, the study found. BMPs are not only closely related to the occurrence and development of bone tumor diseases, but also