【摘 要】
：
目的 研究NF-κB、villin蛋白的表达与胃癌临床病理特征及患者预后的相关性.方法 收集36例胃癌患者组织和对应的癌旁组织36例,每年对患者进行随访,采用免疫组化和蛋白印迹法检测胃癌组织和癌旁组织中NF-κB、villin蛋白的表达,将NF-κB、villin蛋白的表达与胃癌患者临床病理特征及预后情况进行相关性分析.结果 NF-κB、villin蛋白在胃组织中的阳性表达率显著高于癌旁组织中的表达率(P＜0.05);NF-κB、villin蛋白在胃组织中蛋白表达显著高于癌旁组织的表达(P＜0.05) N
【机 构】
：
青海省第五人民医院,青海西宁810000
论文部分内容阅读
目的 研究NF-κB、villin蛋白的表达与胃癌临床病理特征及患者预后的相关性.方法 收集36例胃癌患者组织和对应的癌旁组织36例,每年对患者进行随访,采用免疫组化和蛋白印迹法检测胃癌组织和癌旁组织中NF-κB、villin蛋白的表达,将NF-κB、villin蛋白的表达与胃癌患者临床病理特征及预后情况进行相关性分析.结果 NF-κB、villin蛋白在胃组织中的阳性表达率显著高于癌旁组织中的表达率(P＜0.05);NF-κB、villin蛋白在胃组织中蛋白表达显著高于癌旁组织的表达(P＜0.05) NF-κB的表达与肿瘤浸润深度相关,与转移情况、临床分期呈正相关(P＜0.05),villin蛋白的表达与临床指标无关(P＞0.05);生存分析显示NF-κB的表达与胃癌患者生存预后相关.结论 NF-κB、villin蛋白的表达参与胃癌的发生发展过程,NF-κB的表达与转移情况、临床分期相关,NF-κB、villin蛋白的高表达也表明患者预后情况不良.
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