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目的了解麻疹减毒活疫苗(Measles Attenuated Live Vaccine,MV)强化免疫活动(SupplementaryImmunization Activities,SIA)疑似预防接种异常反应(Adverse Events Following Immunization,AEFI)发生情况。方法对青海省2010年MV SIA出现的AEFI开展监测、调查和分析。结果全省共报告AEFI30例,发生率为6.72/10万剂,一般反应、异常反应分别报告22例、8例;异常反应中,过敏性皮疹占62.50%。发生率随着年龄增大逐步降低;90%发生在接种后1d内。结论 MV的安全性良好,接种后AEFI发生率较低、应进一步提高接种和监测质量。
Objective To investigate the suspected occurrence of Adverse Events Following Immunization (AEFI) by Measles Attenuated Live Vaccine (MV) Supplementary Immunization Activities (SIA). Methods The AEFI in MV SIA in Qinghai Province was monitored, investigated and analyzed in 2010. Results A total of 30 AEFI cases were reported in the province, with an incidence of 6.72 / 10 000 doses. The general and abnormal reactions were reported in 22 and 8 cases respectively. In the abnormal reaction, the allergic rash accounted for 62.50%. The incidence decreased gradually with age; 90% occurred within 1 day after inoculation. Conclusion The safety of MV is good, and the incidence of AEFI after vaccination is low. The quality of inoculation and monitoring should be further improved.